Shenzhen Bineogen Technology Co., Ltd.


Bioimaging and data analysis solutions



Product introduction

Product introduction


We have established a fully staffed, high-end mesoscopic imaging facility.
Delivering a full-service workflow: from sample clearing to 3D imaging and analysis.

Mouse whole-brain imaging service

Provide a series of preparation processes for mouse brains for customers, including tissue clearing and sectioning, and perform VISoR 3D fluorescence imaging (National Science Review, 2019). The final deliverable is the reconstructed micrometer-resolution 3D imaging data. Equipped with self-developed image viewing software, you can easily browse TB-level collected data (Video Link)。

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c-Fos counting analysis service

The mouse whole-brain cell detection (c-Fos counting analysis) service focuses on the precise quantification of neuronal activation states, suitable for studying neural activity patterns, learning and memory, emotional regulation, pain perception, drug effects, and more. c-Fos is an immediate early gene, and its expression level reflects the excitability of neurons.
Through high-resolution 3D fluorescence imaging and automated cell detection algorithms, this service can accurately identify c-Fos positive cells (National Science Review, 2024), quantify their spatial distribution, and register to standard brain atlases, facilitating in-depth analysis of neural circuit activity patterns (Video Link)。

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Mouse whole-body 3D imaging and visualization service

Whole-body imaging service uses innovative ARCHmap and Blockface-VISoR system (Cell, 2025), providing subcellular resolution and system-level whole-body tissue 3D imaging solutions. Through efficient sample clearing and imaging technology, we can clearly resolve the mouse whole-body neural network, organ structure, and their complex interaction patterns (Video Link）。

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Recent News

The world's fastest "high-definition CT" for the whole body of mice! Single nerve fibers are clearly visible

Professors Guoqiang Bi and Beiming Liu from the University of Science and Technology of China, Hefei National Research Center for Microscale Material Science and the School of Life Sciences and Medicine, in collaboration with the team from the Hefei Comprehensive National Science Center's Artificial Intelligence Research Institute and the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, have achieved significant breakthroughs in the field of large-scale biological tissue 3D microscopic imaging. The team has successfully developed

Training Review | 2025 Neural Circuit Tracing and Regulation Conference · Training Class

Shenzhen Bineogen Technology Co., Ltd. Training Course Introduction: The "2025 Neural Circuit Tracing and Regulation Conference · Training Course and Frontier Technology Innovation Conference on Acupuncture Research" successfully concluded in Shenzhen on May 30. This grand event focuses on cutting-edge technologies in the field of neuroscience, attracting many active researchers in neural circuit structure analysis...

Annotation and Visualization of 3D Whole Brain Imaging Data

Lychnis-viewer is a free software specifically designed for large-scale 3D/4D image data, mainly used for annotation and visualization of biological images such as neuron tracing. It supports multi-resolution data display and can efficiently process TB-level Imaris IMS documents...

“Progress in science depends on new techniques, new discoveries, and new ideas,
probably in that order.”
Sydney Brenner

Core technology

Whole brain clearing

After the improved clearing based on the CLARITY method, light passes through the brain slices without emission refraction, allowing uniform and clear 3D imaging within a thickness range of 300μm, revealing the fine structures inside the brain slices.

VISoR high-throughput 3D imaging

Using the VISoR high-throughput technology developed by Prof. Bi's team, we can complete whole mouse brain imaging at 1x1x2.5 μm3 resolution in just 0.5 hours.

Large-Scale Image Analysis

Using high-performance clusters and custom algorithms, we achieve storage, management, and analysis of large image data, including stitching, 3D reconstruction, registration, and neuronal reconstruction.

VISoR imaging


Ultra-high-speed, high-resolution imaging
VISoR can achieve sub-micron resolution imaging, and the imaging speed is very fast, providing an efficient tool for research.

Short sample preparation time, not limited by size
The sample preparation time required for VISoR is relatively short and is not limited by the size of the original sample, which reduces the complexity of experimental preparation (Nature Biotechnology, 2021; Nature Methods, 2025)。


Application Examples

Integrity. Quality. Speed. We handle the details so you can focus on the science -
hassle-free, worry-free, and happy!

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