Chronic pain is a global public health problem. A recent Nature paper completely mapped a "spinal cord-brain-spinal cord" loop causing chronic mechanical pain. Finding the "exclusive loop": Why does pain last when wounds heal? The team found peripheral nerve injury activates a complex closed loop: signals go from spinal cord to thalamus and primary somatosensory cortex, then to spinal OPRM1+ RVMSC neurons. Excitingly, "closing" any node stops chronic pain without hurting normal pain feeling, guiding new painkillers without side effects.
Morphological evidence that leaves reviewers impeccable
In peer review, the reviewers pointed out that to prove such a complex circuit spanning multiple brain regions, extremely high-precision neural projection evidence must be provided. To this end, the research team used whole-brain clearing (TESOS) technology and performed precise single-axon tracing in complex image data. These clear, visible, and precise 3D reconstructed images became the "ironclad evidence" that completely convinced the reviewers.
And the core software used back in the article to complete this massive tracking project -Lychnis, exactly fromShenzhen Bineogen Technology Co., Ltd.a core research tool strongly maintained and supported. Thanks to Lychnis's excellent big data processing performance and smooth 3D spatial rendering technology, scientists have successfully drawn the beautiful and complex projection trajectories of these key neurons in deep tissues, providing the most core morphological evidence for publication!
From software to platform: Bineogen's one-stop mesoscopic imaging service
We deeply know that for the majority of brain science researchers, to obtain morphological charts that meet the standards of top journals, they face numerous obstacles: unstable clearing processing, lack of expensive imaging equipment, and massive 3D data that is difficult to process...
To thoroughly address these research pain points,Shenzhen Bineogen Technology Co., Ltd. relies on the "Shenzhen Brain Science Industry Innovation Center" to heavily build a top mesoscopic imaging platform!
We not only provide support for the Lychnis software but also have a batch of complete high-end equipment and an experienced professional technical team, providing you withEnd-to-end service from specimen to data：
- Sample clearing processing: Standard process for the best optical clearness of your sample tissue;
- 3D scanning imaging: Mesoscale high-resolution imaging - VISoR, catching every detail inside nerve fibers;
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Advanced data analysis：
- Single neuron/axon 3D reconstruction；
Whole-brain atlas registration andAutomated quantitative counting of cell markers such as c-Fos。
Conclusion
Scientific research is a war without smoke, and high-quality image data is your most powerful weapon. Shenzhen Bineogen's mesoscopic imaging platform is committed to becoming your "super external brain" in exploring the mysteries of the brain. Leave the tedious sample preparation, scanning, and analysis to us, and let your team invest precious time in thinking about core scientific issues!
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Original article: Wang, Q., Lee, J.H., Nachtrab, G. et al. Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain. Nature (2026).
Link: https://doi.org/10.1038/s41586-026-10296-y