The ultra-micro fluorescence microscopy system (TINISCOPE series) adopts a smaller CMOS chip with serial output functionality, eliminating the need for a serializer chip, and integrates the power supply support chip and oscillator functionality into the data acquisition system (DAQ). This innovative design significantly reduces the size and weight of the CMOS module, allowing users to achieve synchronous imaging of almost any four target brain regions. Tests show that mice can move freely with four devices worn simultaneously without significant impact.

TINISCOPE provides neuroscientists with a new important research tool to explore the neuron-level cross-brain region coordination mechanisms in animals' perception, cognition, and behavior.